Alternative diagnoses in wheezy children

This content is from the BTS/SIGN British guideline on the management of asthma (SIGN 158), 2019.

Clinical clue Possible diagnosis
Symptoms present from birth or perinatal lung problem Cystic fibrosis; chronic lung disease of prematurity; ciliary dyskinesia; developmental lung anomaly
Family history of unusual chest disease Cystic fibrosis; neuromuscular disorder
Severe upper respiratory tract disease Defect of host defence; ciliary dyskinesia
Symptoms and signs
Persistent moist cough78 Cystic fibrosis; bronchiectasis; protracted bacterial bronchitis; recurrent aspiration; host defence disorder; ciliary dyskinesia
Excessive vomiting Gastro-oesophageal reflux (with or without aspiration)
Paroxysmal coughing bouts leading to vomiting Pertussis
Dysphagia Swallowing problems (with or without aspiration)
Breathlessness with light-headedness and peripheral tingling Dysfunctional breathing, panic attacks
Inspiratory stridor Tracheal or laryngeal disorder
Abnormal voice or cry Laryngeal problem
Focal signs in chest Developmental anomaly; post-infective syndrome; bronchiectasis; tuberculosis
Finger clubbing Cystic fibrosis; bronchiectasis
Failure to thrive Cystic fibrosis; host defence disorder; gastro-oesophageal reflux
Investigations
Focal or persistent radiological changes Developmental lung anomaly; cystic fibrosis; postinfective disorder; recurrent aspiration; inhaled foreign body; bronchiectasis; tuberculosis

 

         

References

  1. 78. Marchant JM, Masters IB, Taylor SM, Chang AB. Utility of signs and symptoms of chronic cough in predicting specific cause in children. Thorax 2006;61(8):694-8.