- Blood cultures x 2 sets from separate sites
- Joint aspirate fluid sent for culture (contact microbiology to arrange urgent Gram stain)
Septic arthritis
Do not start antibiotic therapy until samples obtained.
Discuss all cases with microbiology and orthopaedics/rheumatology
Recommended total duration: 4 weeks
Recommended antibiotic | Flucloxacillin 2g every 6 hours IV |
Penicillin Allergy OR previous MRSA colonisation or infection |
Vancomycin IV (use NHS Lothian Calculator on AMT intranet page); aim trough levels 15-20mg/L |
These groups are at a higher risk of Gram-negative infection
- elderly
- frail
- recurrent UTI
- recent urological or abdominal surgery
Discuss with microbiology early if concerns regarding Gram negative infection.
CONSIDER
Gentamicin IV Use NHS Lothian Calculator located AMT intranet page
Depends on microbiological investigations and whether septic arthritis is confirmed
- Intravenous therapy recommended for a prolonged proportion of treatment.
- In stable patients consider referral to OPAT.
- Likely organisms: Staphylococcus aureus, Streptococci, Enterobacteriacae, Neisseria gonorrhoea
- Where gonococcal infection is suspected take appropriate samples (genital, urine, throat, rectal as required) for combined Chalmydia/Gonorrohoeal NAAT testing (get the right sampling kit) - joint fluid can be tested by PCR for gonorrhoea in discussion with microbiology.