Treatment of second recurrence of CDI

Review severity markers (see Severity of Infection) and contact infection specialist for advice (see How to get advice).

Faecal microbiota transplant (FMT) is recommended and requires referral to infectious diseases - bleep 8161.

If FMT not available considering tapering oral vancomycin regime as below:

Tapering vancomycin course

Week 1 - Vancomycin 125mg every 6 hours

Week 2 - Vancomycin 125mg every 12 hours

Week 3 - Vancomycin 125mg daily

Week 4 - Vancomycin 125mg alternate days

Week 5 - Vancomycin 125mg every third day

If further recurrences specialist advice is required (see How to get advice).