Treatment of first recurrence of CDI

Review severity markers (see Severity of Infection) and contact infection specialist for advice (see How to get advice).

Recurrence of CDI within 12 weeks (= relapse)

Fidaxomicin 200mg every 12 hours orally

Duration = 10 days

Exception – treatment failure identified as incomplete treatment course. Treat as per first episode of CDI with vancomycin 125mg every 6 hours orally for 10 days.

Recurrence of CDI after 12 weeks (= recurrence)

Vancomycin 125 mg every 6 hours orally

Duration = 10 days