Prophylaxis

Important: Therapy

Co-amoxiclav 1.2g IV

 

If weight >100kg give additional dose of Amoxicillin 1g IV

(i.e. total dose = 2g Amoxicillin and 200mg clavulanic acid)

Notes:

If BMI >35 continue Co-amoxiclav 625mg PO 8 hourly for 24hr post-op

Prophylaxis - Penicillin Allergy

Important: Therapy

Clindamycin 600mg IV AND Gentamicin IV (refer to Drug Dosing Table)

Weight >80kg: increase Clindamycin dose to 900mg IV

Weight >160kg: increase Clindamycin dose to 1200mg IV

Notes:

If BMI >35 continue Clindamycin 300mg PO 6 hourly for 24hr post-op

Prophylaxis - MRSA Positive Patient

Important: Therapy

ADD Teicoplanin to above prophylaxis (refer to Drug Dosing Table)

Notes:

No additional oral antibiotic required for 24hr post-op

Important: Notes

All antibiotic doses should be given pre-skin incision.

Ensure that appropriate antibiotic re-dosing if >1.5 litre blood loss as per Drug Dosing Table (after fluid replacement)