Acute exacerbation of COPD

Many exacerbations (including some severe exacerbations) are not caused by bacterial infections so will not respond to antibiotics

NICE NG 114

Treat exacerbations promptly with antibiotics if purulent sputum and increased shortness of breath and/or increased sputum volume.

Risk factors for antibiotic resistant organisms and clinical failure include frailty, co-morbid disease, severe COPD (MRC>3), frequent exacerbations, antibiotics in last 3 months.

If treatment failure, send sputum samples for sensitivity testing.

Drug details

First choice

Amoxicillin

500mg TDS

5 days

Or

Doxycycline

200mg stat then 100mg OD

5 days

If higher risk of clinical failure (see Comment above):

Guided by recent microbiological cultures or Co-trimoxazole

960mg BD

5 days