Note: Low doses of penicillins are more likely to select out resistance1, we recommend 500mg of amoxicillin. Do not use quinolone (ciprofloxacin, ofloxacin) first line due to poor pneumococcal activity.2B- Reserve all quinolones (including levofloxacin) for proven resistant organisms and see MHRA advice on prescribing of fluoroquinolones here. AVOID tetracyclines in pregnancy.