Treatment of patients who do not require supplemental oxygen

Patients with COVID-19 who DO NOT require supplemental oxygen therapy and are thought to be at high risk of progression to severe COVID-19 may be eligible for:

Nirmatrelvir plus ritonavir (Recommended)

- Sotrovimab (Recommended)

- Molnupiravir (conditional recommendation)

- Remdesivir [3 days] (conditional recommendation)

 

Definitions:

Recommended

A strong recommendation is given when there is high-certainty evidence, or lower-certainty evidence paired with consistent panel expertise, showing that the overall benefits of the intervention are clearly greater than the disadvantages. This means that all, or nearly all, patients will want the recommended intervention.

 

Conditional recommendation

A conditional recommendation is given when it is considered that the benefits of the intervention are greater than the disadvantages, or the available evidence cannot rule out a significant benefit of the intervention while assessing that the adverse effects are few or absent. This recommendation is also used when patient preferences vary.

 

Adapted from NICE COVID-19 rapid guideline: Managing COVID-19 - Therapeutics for COVID-19