Complicated UTI (including urinary sepsis and pyelonephritis)

First Line

Important: Therapy

Co-amoxiclav 625mg PO 8 hourly

or

Cefalexin 1.5g PO 8 hourly

Notes:

If oral route compromised:

Ceftriaxone 2g IV 24 hourly 

Second Line

Important: Therapy

Co-trimoxazole 960mg PO 12 hourly

Notes:

If oral route compromised:

Ceftriaxone 2g IV 24 hourly 

Severe Infection

Important: Therapy

Ceftriaxone 2g IV 24 hourly

or

Ciprofloxacin 500mg PO/IV 12 hourly (consider safety issues)

Notes:

Important: Notes

Send blood culture and urine and follow up results

Check previous urine results which may help guide antibiotic choice

Treatment duration: 7 days