First Line

Important: Therapy

Gentamicin IV (as per online calculator) AND Amoxicillin 1g IV 8 hourly AND Metronidazole 500mg IV 8 hourly 

- if Staphylococcal infection suspected (eg IVDU) ADD Flucloxacillin 2g IV 6 hourly

 

Notes:

- If concerns regarding nephrotoxicity e.g. acute kidney injury - replace Gentamicin with Temocillin IV as per High Dose Antibiotic Therapy guidance 

- Metronidazole should be prescribed PO after initial IV dose if oral route appropriate as highly bioavailable.

Penicillin Allergy

Important: Therapy

Vancomycin IV (as per online calculator) AND Gentamicin IV (as per online calculator) AND Metronidazole 500mg IV 8 hourly

Notes:

- If concerns regarding nephrotoxicity e.g. acute kidney injury - replace Gentamicin with Aztreonam IV dosed per Renal Drug Database

- Metronidazole should be prescribed PO after initial IV dose if oral route appropriate as highly bioavailable.

Important: Notes

Send blood cultures  and other relevant samples

Check previous / recent microbiology results for guidance

Check previous MRSA status

 

Treatment duration: Guided by source of infection after investigation and clinical response. Refer to appropriate header in guidance. 

 

If there is treatment failure/relapse check microbiology results, seek senior clinical review +/- discuss with Microbiology consultant.