First Line

Important: Therapy

If < 5days since admission:

Amoxicillin 1g IV 8 hourly AND Metronidazole 500mg IV 8 hourly

 

 If ≥ 5 days since admission, severe infection, sepsis:

Amoxicillin 1g IV 8 hourly AND Metronidazole 500mg IV 8 hourly AND Gentamicin IV as per protocol

Notes:

Penicillin Allergy

Important: Therapy

Co-trimoxazole 960mg IV 12 hourly AND Metronidazole 500mg IV 8 hourly

 

If ≥ 5 days since admission and severe infection / sepsis:

Levofloxacin 500mg IV 12 hourly (consider safety issues) AND Metronidazole 500mg IV 8 hourly 

 

Notes:

Enteral route can be used if deemed appropriate e.g. safe swallow, via NG 

Important: Notes

Send sputum when possible

Treatment duration: 5-7 days. If very prompt clinical response 3 days may be adequate.

Review daily for IV to PO switch