Native Valve endocarditis - PLUS sepsis

First Line

Important: Therapy

Vancomycin IV as per protocol AND Gentamicin IV as per protocol (Treatment dose)

Notes:

If acute kidney injury, replace Gentamicin with Ciprofloxacin 750mg PO 12 hourly or 400mg IV 8hourly (consider safety issues)

If true vancomycin allergy, replace with Daptomycin 6mg/kg IV daily (monitor CK)