Native Valve Endocarditis - Indolent presentation

First Line

Important: Therapy

Amoxicillin 2g IV 4 hourly AND Gentamicin 1mg/kg IV 12-hourly (synergistic dose - up to a maximum of 120mg 12-hourly)

 

Notes:

If acute kidney injury, replace Gentamicin with Ciprofloxacin 750mg PO 12 hourly or 400mg IV 8hourly (consider safety issues)

Penicillin Allergy

Important: Therapy

Vancomycin IV as per protocol AND Gentamicin IV as per protocol (Treatment dose)

 

Notes:

If acute kidney injury, replace Gentamicin with Ciprofloxacin 750mg PO 12 hourly or 400mg IV 8hourly (consider safety issues)

If true vancomycin allergy, replace with Daptomycin 6mg/kg IV daily (monitor CK)

 

Important: Notes

Prescribe on HEPMA using the file: 'Gentamicin IV STAT / Endocarditis / Synergy / Nebulised' specifying the dose (e.g. 80mg BD)
Aim for a 1 hour post dose peak of 3-5 mg/L and a trough of <1 mg/L
Take a first peak level 1 hour after the first dose and the first trough level immediately prior to second dose. Ensure the dosing & sample time are recorded accurately. 
Doses should be given by IV bolus injection over 3-5 minutes.

If renal function is poor or deteriorating, discuss dosing and frequency with pharmacist ASAP