Skin, Soft Tissue and Musculoskeletal

Cellulitis

Not facial.
Not associated with bites

For preseptal or periorbital cellulitis see Ophthalmology guidance: periorbital or preseptal cellulitis

Treatment 

Flucloxacillin (IV or oral)

If true penicillin allergy:

Clindamycin (IV or oral)

Duration: 7 days

Necrotising fasciitis

Seek surgical review. Urgent surgical debridement is crucial.

Theatre specimens should be sent for microscopy and culture to help determine aetiology. Contact microbiology labs to arrange urgent examination.

Treatment

Meropenem IV (Maximum dose)

Plus

Clindamycin IV (Maximum dose)

Gas gangrene

The primary treatment for this condition is urgent surgical debridement.

Antibiotics have only a secondary role in therapy.

Gangrene develops in anaerobic areas with limited blood flow. Therefore, antibiotics do not penetrate and only protect contiguous areas.

Treatment

Benzylpenicillin IV

Plus

Clindamycin IV

If true penicillin allergy:

Vancomycin IV

Plus

Clindamycin IV

Bites (human / cat / dog)

Give antibiotic prophylaxis in all human, cat, dog and puncture bites, especially when hand, foot, face, joint, tendon, ligament involved; or when patient immunocompromised, diabetic, asplenic, cirrhotic, presence of prosthetic valve or prosthetic joint

If accompanied by marked cellulitis consider parenteral antibiotic therapy and seek plastic surgery advice.

Wound care and irrigation is very important

Consider tetanus prophylaxis

Assess risk of tetanus; HIV; hepatitis B&C; in human bites and rabies in animal bites

If bite was sustained abroad or if any other animal was involved, seek Microbiology advice

Treatment

Co-amoxiclav IV or Oral

If true penicillin allergy:

Co-trimoxazole Oral

Plus

Metronidazole Oral

Duration: 7 days

Post-operative wound infection

Clean procedure

Flucloxacillin IV

If true penicillin allergy:

Clindamycin IV

If MRSA risk:

Vancomycin IV

Contaminated procedure

Co-amoxiclav IV

If MRSA risk:

Add Vancomycin IV

If true penicillin allergy:

Vancomycin IV

Plus

Ciprofloxacin IV (before prescribing review MHRA Safety Advice )

Plus

Metronidazole IV

Send a wound swab for culture prior to initiating treatment. Further therapy should be guided by laboratory results.

Acute Bone and Joint Infections

Take blood cultures and send joint aspirates for culture before starting empirical antibiotic therapy.

Septic arthritis or Acute Osteomyelitis
Age: 0-3 months old

Cefotaxime IV

If true penicillin allergy:

Contact Microbiology

Initial intravenous therapy for 14 days, then duration of oral therapy will depend on sensitivities. If cultures negative then use 4 weeks oral co-amoxiclav

Age: >3 months

Flucloxacillin IV

Plus

Clindamycin IV

If true penicillin allergy:

Clindamycin IV

Initial intravenous therapy for 72 hours, then duration of oral therapy will depend on sensitivities. If cultures negative then use 4 weeks oral co-amoxiclav

In all cases seek specialist orthopaedic advice at the outset.

Do not start antibiotic therapy until appropriate samples have been obtained for culture.

In children >3 months to 5 years of age consider Kingella kingae. If unresponsive to initial therapy consider changing to ceftriaxone.

Chronic osteomyelitis

Seek specialist orthopaedic advice.

Appropriate specimens should be taken for culture prior to starting therapy