Respiratory tract infections

Community-acquired pneumonia

CURB-65 score can help assess severity.

Score 1 point for each of:

  • New confusion (AMT ≤ 8)
  • Urea > 7 mmol / L
  • Resp rate ≥ 30 / minute
  • BP (diastolic ≤ 60 mmHg or systolic < 90 mmHg)
  • Age ≥ 65

Treatment regimens are suitable for use in patients with or without suspected or known COVID-19 infection

Treat only if there is clinical suspicion of bacterial infection, such as purulent sputum, or evidence of consolidation

CURB 65 = 0-1

ORAL

DOXYCYCLINE 200mg stat, then 100mg OD

Or

AMOXICILLIN 1g TDS

INTRAVENOUS

AMOXICILLIN 1g TDS

Duration 5 days

CURB 65 = 2

ORAL

AMOXICILLIN 1g TDS

Plus

DOXYCYCLINE 200mg stat, then 100mg OD

True penicillin allergy:

DOXYCYCLINE (monotherapy) 200mg stat, then 100mg OD

INTRAVENOUS - Seek medical advice

AMOXICILLIN 1g TDS

Plus

DOXYCYCLINE (PO) 200mg stat, then 100mg OD

True penicillin allergy:

COTRIMOXAZOLE 960mg BD (eGFR >35)

True penicillin allergy AND eGFR is <35

LEVOFLOXACIN (refer to SPC for dosing in renal impairment)

Duration: 5 days

CURB 65 = 3 or greater

No suitable initial oral treatment

Seek medical advice

INTRAVENOUS

CO-AMOXICLAV 1.2g TDS

Plus

DOXYCYCLINE 200mg stat, then 100mg OD

True penicillin allergy:

COTRIMOXAZOLE 960mg BD (eGFR >35)

True penicillin allergy AND eGFR is <35

LEVOFLOXACIN (refer to SPC for dosing in renal impairment)

Duration: 5 days

Exacerbation of COPD with clinical evidence of bacterial infection

ORAL

DOXYCYCLINE 200mg stat, then 100mg OD

Or

AMOXICILLIN 1g TDS

If clinical failure of oral therapy, send sputum and consider CO-AMOXICLAV 625mg TDS PO / 1.2g TDS IV

INTRAVENOUS

AMOXICILLIN 1g TDS

Duration 5 days

Aspiration Pneumonia

ORAL

CO-AMOXICLAV 625mg TDS

True penicillin allergy:

Discuss with Microbiology

INTRAVENOUS

CO-AMOXICLAV 1.2g TDS

True penicillin allergy:

Discuss with Microbiology

Duration: 5-7 days

Hospital or Nursing Home acquired Pneumonia

ORAL

DOXYCYCLINE 200mg stat, then 100mg OD

Or

COTRIMOXAZOLE 960mg BD (eGFR >35)

INTRAVENOUS

AMOXICILLIN 1g TDS

Plus

GENTAMICIN

Dose as per calculator

If IV treatment is still needed after three days, convert GENTAMICIN to:

TEMOCILLIN 2g TDS

True penicillin allergy:

Discuss with Microbiology

Duration 5-7 days