Spontaneous Bacterial Peritonitis (SBP)

Antimicrobial prescribing: NHS Borders
NHS Borders

Duration

5-7 days

First Line

Therapy

Ceftriaxone 2g IV 24 hourly

Notes:

Or, in Immediate (type 1) beta-lactam sensitivity

Therapy

Vancomycin IV (dosing as per guidelines. Use vancomycin calculator)

+

Ciprofloxacin oral 500mg 12 hourly (IV if enteral route unavailable).

Consult Microbiologist if patient has been receiving a quinolone as SBP prophylaxis.

Notes:

Prophylaxis of Spontaneous Bacterial Peritonitis

Therapy

Co-Trimoxazole 960mg oral daily.

If alternative regimen required, discuss with Consultant Microbiologist

Notes:

Notes

Fluroquinolones

Refer to important safety information for all quinolones prior to prescribing.

See MHRA Drug Safety Update January 2024: Fluoroquinolones must only be used in situations when other antibiotics, that are commonly recommended for the infection, are inappropriate such as:

  • there is resistance to other first-line antibiotics recommended for the infection
  • other first-line antibiotics are contraindicated in an individual patient
  • other first-line antibiotics have caused side effects in the patient requiring treatment to be stopped
  • treatment with other first-line antibiotics has failed