Immune-related skin toxicity pathway

Immune-related skin toxicity pathway

STARTFINISHCreated with SnapWhat grade?STARTFINISHCreated with SnapGrade 1Macules/papulescovering <10% thebody surface area(BSA) with or withoutsymptoms (e.g....STARTFINISHCreated with SnapAssessmentPhysical assessment.Exclude other causes(viral illness, infection,other drug rash)STARTFINISHManagementSee info for details.STARTFINISHCreated with SnapGrade 2Macules/papulescovering 10%-30%BSA with or withoutsymptoms (e.g.pruritus, burning,...STARTFINISHCreated with SnapAssessment- As per grade 1- Bloods- Considerdermatology review(biopsy +...STARTFINISHCreated with SnapManagementSee info for details.STARTFINISHFollow-up- Review weekly- If no improvementtreat as G3STARTFINISHCreated with SnapGrade 3Macules/papulescovering >30% BSAwith or withoutassociated symptoms;limiting selfcare ADLSTARTFINISHCreated with SnapAssessment- Admit- As per grade 1- Bloods- Urgent dermatologyreview (biopsy +...STARTFINISHCreated with SnapManagementSee info for detailsSTARTFINISHFollow-up- Mild to moderate:wean steroids over1-2 weeks- Severe: weansteroids over 2-4...STARTFINISHCreated with SnapGrade 4Papulopustular rashassociated withlife-threateningsuperinfection:Stevens-Johnson...STARTFINISHCreated with SnapAssessment- Admit- As per grade 1- Bloods- Urgent dermatologyreview (biopsy +...STARTFINISHManagementSee info for details