Outpatient management of low risk adult oncology patients with febrile neutropenia

Warning

Part 1 - Triage and initial management - see Febrile neutropenia management pathway: important notes.

Part 2 - Identification of candidates for outpatient management.

Use a validated scoring system to assess level of risk for serious medical complications associated with febrile neutropenia- MASCC (available also as an MDCalc online calculator or app) 

MASCC risk score pathway

Oral empirical antibiotic therapy for candidates felt suitable for outpatient management:

Discharge checklist

  1. All cases of discharge should be discussed with the on-call oncology registrar contactable via switchboard so that patients can be added to the ‘call back’ list.
  2. Patients should have hourly obs for ≥ 4 hours before discharge and only discharged if condition stable.
  3. Residence ≤ 1 hour from nearest emergency department.
  4. Must have a family member or caregiver at home.

Follow up

Callback from cancer assessment unit triage team daily for 3 days following discharge to assess symptoms over the phone and chase any outstanding test results (for example urine and blood cultures)

Low threshold for admission to hospital if:

  • Continues to have fevers 48 hours after broad spectrum empirical oral antibiotics.
  • New signs or symptoms or infection.
  • Blood culture results identify species not susceptible to the initial regime.
  • Develop breathlessness, cough or myalgia.

Editorial Information

Last reviewed: 05/01/2024

Next review date: 05/01/2027

Author(s): Edinburgh Cancer Centre.

Version: 1.0

Approved By: Authorised by CTAC. Refer to Q-Pulse for approval details

Reviewer name(s): Stewart J.