Appendix 2: Potential drug interactions of apixaban

Warning

Potential drug interactions of apixaban45

CYP3A4 and P-glycoprotein interactions Examples Potential interaction with apixaban
Strong inhibitors of both CYP3A4 and P-gp ketoconazole, itraconazole, voriconazole, HIV protease inhibitors (e.g. ritonavir)

Can increase apixaban concentrations.

Potential for increased bleeding risk.

Strong inducers of both CYP3A4 and P-gp phenytoin, carbamazepine, phenobarbital or St. John's Wort

Can reduce apixaban concentrations.

Efficacy of apixaban may be compromised.

For further information consult the apixaban SMPC 

https://www.medicines.org.uk/emc/product/2878/smpc

Editorial Information

Last reviewed: 01/12/2021

Next review date: 01/12/2024

Author(s): Dalrymple H.

Version: 2.1

Approved By: CTAC Chair

Reviewer name(s): Stewart J.