Anxiolytic premedication (Paediatric Guidelines)

Warning

Audience

  • North NHS Highland only 
  • Secondary Care only
  • Children only

This document is designed to guide the prescription and administration of sedative pre-medication in children requiring elective or emergency surgery.

  • It covers both standard options and second-line options in children where a single agent may not produce adequate sedation and anxiolysis.
  • Clinicians are advised to familiarise themselves with these strategies, although they are not exhaustive.
  • Doses, agents and routes can be altered at the discretion of a senior anaesthetist.

Care planning

Anxiolytic premedication may not be required

Non-pharmacological anxiolysis strategies should always be employed, even when utilising sedative premedication

  • The ideal scenario involves identification of potential patients benefiting from these interventions during their pre-operative assessment process, or earlier, and liaison with the named anaesthetist for that list.
  • Discussion with the care givers and patient (as appropriate) is vital to success; this will help inform chosen route of administration
  • Enquiries about previous experiences may inform chosen strategy; anaesthetic records may provide additional information;
    • Midazolam may have idiosyncratic paradoxical excitatory effects in those with ADHD, or on the autistic spectrum.
    • Clonidine is a useful alternative, or can be included alongside midazolam to minimise these effects.
  • Oral, buccal or intranasal routes are preferred wherever possible.
    • Appropriate safety measures should be put in place if choosing to administer IM drugs to minimise risk to patients, staff and other caregivers.
  • Oral medications can be combined in a single enteral syringe or mixed with a small volume of water or diluting juice.
    • IV preparation of clonidine can easily be administered enterally as it is concentrated and has no appreciable taste or odour.
  • Minimum standards of monitoring as per the AAGBI must be adhered to; this includes waveform capnography if moderate/deep sedation is required prior to entering the anaesthetic room.
  • Means of providing airway and respiratory support must also be prepared and immediately to hand if deep sedation techniques are employed to facilitate transfer to the theatre suite; a trained airway assistant must also be present.
  • Administration of anxiolytics may be required on rare occasions outside the hospital building, for example in the car park.
    • These instances should be agreed in advance, with appropriate planning involving all relevant parties.
    • The oral, buccal or intranasal routes are still preferred if possible.
    • Appropriate preparations should be made to provide respiratory, cardiovascular and ongoing sedation requirements in this setting (i.e. appropriately trained staff, thorough briefing, availability of trolley, oxygen, airway support and monitoring).

Administration & monitoring:

  • Administer at the prescribed time, or as soon as requested by telephone instruction.
  • The child should be appropriately monitored: 
    • SpO2 as a minimum for midazolam or ketamine techniques; see note below
    • and NOT left unattended at any point after administration.
  • If rapid or deep sedation techniques are employed (eg, intranasal midazolam, IM ketamine) a trained anaesthetist should be present;

First line

Option A: Midazolam

0.5mg/kg, oral or buccal

Maximum 20mg

20 to 30 minutes prior to transfer to theatre suite

Option B: Midazolam

0.3mg/kg, intranasal 15 to 20 minutes prior to transfer to theatre suite

Second line

Clonidine

2 microgram/kg, oral At least 45 minutes prior to transfer to theatre suite
Third Line

Clonidine

2 microgram/kg, oral

At least 45 minutes prior to transfer to theatre suite.

  • Addition of midazolam after 30 minutes, if needed.

Midazolam

0.3 mg/kg, oral or intranasal *Anaesthetist-delivered, if intranasal*
Fourth Line

Ketamine

2 to 10 mg/kg, intramuscular

*50mg/mL*

5 to 10 minutes prior to transfer to theatre suite.

  • Higher doses will provide rapid anaesthesia.
  • If using a higher dose: may be best to stagger incremental doses due to volume required, eg: 2 to 5 mg/kg at time “0”, then repeated if needed after 5 to 10 minutes.

Abbreviations

  • AAGBI: Association of Anaesthetists of Great Britain and Ireland
  • IM: intramuscular

Editorial Information

Last reviewed: 28/08/2025

Next review date: 28/08/2028

Author(s): Paediatrics.

Version: 2

Approved By: TAM Subgroup of ADTC

Reviewer name(s): Dr H Robinson, Consultant Anaesthetist, M Dunbar, Lead Pharmacist, Women and Child , Dr I Thompson, Consultant Anaesthetist.

Document Id: TAM470