Leukotriene receptor antagonists (Formulary)

TAM (Treatments and Medicines) NHS Highland
NHS Highland
  • Leukotriene receptor antagonists are non-steroidal anti-inflammatory agents that can be used as add-on therapy in persistent asthma or in exercise-induced asthma.
  • The efficacy is variable therefore review patients after a 4 to 8 week period of therapy.
  • Do not start during pregnancy.
  • Advise patients that montelukast is most effective if taken in the evening.

MONTELUKAST

Therapy notes

  • MHRA advice: Montelukast reminder of the risk of neuropsychiatric reactions (April 2024) (www.gov.uk).
  • MHRA advice: Montelukast (Singulair) - reminder of the risk of neuropsychiatric reactions (September 2019) (www.gov.uk).

Formulation and dosage details

Formulation:

Chewable tablets 4mg

Dosage:

Prophylaxis of asthma in children: see BNFC.

Formulation and dosage details

Formulation:

Sugar-free granules 4mg

Dosage:

Prophylaxis of asthma in children: see BNFC.

Formulation and dosage details

Formulation:

Tablets 10mg

Dosage:

Prophylaxis of asthma, adult and child over 15 years: 10mg daily in the evening.

Editorial Information

Document Id: F356