Product Indication Local/National guidance

Intraveneous immunoglobulin (IVIg)

Authoriser: Specialist consultant

Supplier: Issued by pharmacy on receipt of completed  Scottish IVIG Request form

All immunoglobulin indications (including primary immunodeficiency) within national guidance (opposite).

First-line therapy (red) or equal first-line therapy with another medicine(s) (blue) are approved for use within NHS Highland.

Requests for all other indications should follow non-Formulary processes.

Clinical guidelines for immunoglobulin use, 2nd edition update for Scotland

Clinical guidelines for immunoglobulin use, 3rd edition update for Scotland

Anti-D (Rh0) Immunoglobulin 500 units (D-GAM) and 1500 units (Rhophylac)

Authoriser: Medical staff

Supplier:
Raigmore: Pharmacy in association with Blood Transfusion Service.
Caithness General and Belford: Laboratories. 
A&B: tel 01631 789000 (maternal blood type required). 

Prevention of hemolytic disease of the fetus and newborn (HDFN). 

Routine antenatal anti-D prophylaxis  RAADP.

BCSH: Anti-D immunoglobulin for the prevention of haemolytic disease of the fetus and newborn

NICE TA156

Anti-hepatitis B Immunoglobulin injection 500 units

Authoriser: Medical staff

Supplier:  Casualty departments.

Further stock and advice:
Raigmore Pharmacy: 01463 704486.
Caithness General and Belford: Laboratories.
A&B tel: 01631 789000.

Post-exposure prophylaxis

Prevention in at-risk neonates (administered with Hepatitis B vaccine).

Immunoglobulin Handbook

Green Book

Anti-tetanus Immunoglobulin injection 250 units

Authoriser: Medical staff

Supplier:  Casualty departments.

Further stock and advice:
Raigmore Pharmacy: 01463 704486.
Caithness General and Belford: Laboratories.
A&B tel: 01631 789000.

Prophylaxis for tetanus-prone wounds.

Treatment of clinical tetanus.

Immunoglobulin Handbook

Green Book

Anti-varicella zoster Immunoglobulin injection 250 units

Authoriser: Medical staff

Supplier:
Casualty departments.

Further stock and advice:
Raigmore Pharmacy: 01463 704486.
Caithness General and Belford: Laboratories.
A&B tel: 01631 789000.

Post-exposure prophylaxis in high-risk individuals. 

Immunoglobulin Handbook

Green Book

Anti-rabies Immunoglobulin injection

Authoriser: Medical staff

Supplier:
Casualty departments.

Further stock and advice:
Raigmore Pharmacy: 01463 704486.
Caithness General and Belford: Laboratories.
A&B tel: 01631 789000.

Post-exposure prophylaxis (administered with rabies vaccine).

Immunoglobulin Handbook

Green Book

Human Normal Immunoglobulin injection (Subgam 1000mg)

Authoriser: Medical staff

Supplier:
Casualty departments.

Further stock and advice:
Raigmore Pharmacy: 01463 704486.
Caithness General and Belford: Laboratories.
A&B tel: 01631 789000.

Measles prophylaxis for immunocompetent infants and pregnant women as per National Guidance.

Guidelines on Post-Exposure Prophylaxis for measles June 2019 (publishing.service.gov.uk)

Immunoglobulin Handbook

Green Book

NORMAL IMMUNOGLOBULIN

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Solution for intravenous infusion (contact Pharmacy for available brand) (specialist recommendation only)

Important: Formulation and dosage details

Formulation:

Solution for subcutaneous injection (contact Pharmacy for available brand) (specialist recommendation only)

ANTI-D (RHO) IMMUNOGLOBULIN

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Solution for injection 500 units, 1500 units (specialist recommendation only)

ANTIHEPATITIS B IMMUNOGLOBULIN

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Solution for injection 500 units, intramuscular (specialist recommendation only)

ANTITETANUS IMMUNOGLOBULIN

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Solution for injection 250 units, intramuscular (specialist recommendation only)

ANTIVARICELLA-ZOSTER IMMUNOGLOBULIN

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Solution for injection 250mg, intramuscular (specialist recommendation only)

ANTIRABIES IMMUNOGLOBULIN

Important: Therapy notes

Important: Formulation and dosage details

Formulation:

Solution for injection 500 units, intramuscular (specialist recommendation only)

Editorial Information

Last reviewed: 31/08/2023

Document Id: F251