Antacids and simeticone (Formulary)

Refer to Upper GI guidelines

  • Antacids reduce the absorption of a number of drugs, eg ciprofloxacin, some tetracyclines. Separate the administration times of these drugs by at least 1 hour to minimise the effect.
  • Similarly, the administration times of an antacid and enteric-coated tablets should be separated so that the pH-sensitive coating is not destroyed in the stomach.

CO-MAGALDROX - (First line)

Important: Therapy notes

BNF

  • Mucogel® is low in sodium (less than 1mmol per 10mL) and is sugar-free.

Important: Formulation and dosage details

Formulation:

Suspension (Mucogel®) 195/220

Dosage:

10 to 20mL, 20 to 60 minutes after meals and at bedtime or when required.

COMPOUND ALGINATE PREPARATIONS

Important: Therapy notes

BNF

  • Peptac® is sugar-free but has a higher content of sodium (6·2mmol per 10mL); avoid where salt restriction is advisable.
  • Peptac® is beneficial in reflux oesophagitis.

Important: Formulation and dosage details

Formulation:

Chewable tablets (Gaviscon®)

Dosage:

1 to 2 tablets chewed 4 times daily after meals and at bedtime.

Important: Formulation and dosage details

Formulation:

Suspension (Peptac®)

Dosage:

10 to 20mL after meals and at bedtime.

Important: Formulation and dosage details

Formulation:

Infant oral powder sachets (Gaviscon® Infant)

Dosage:

Refer to BNF for Children.

SIMETICONE

Important: Therapy notes

BNF

  • Evidence for the benefit of simeticone in infantile colic is uncertain
  • See patient information for the management of colic.
  • Simeticone is used prior to endoscopy off-label

Important: Formulation and dosage details

Formulation:

Liquid 40mg/mL

Document Id: F219