Protected antimicrobials (Antimicrobial)

Warning
The antimicrobials in tables 1 and 2 are protected. Their use MUST be authorised by a consultant microbiologist or infectious diseases physician.

To ensure timely, appropriate treatment of certain infections, there are specific situations where this authorisation is not immediately required, as detailed in Table 1. However, this authorisation MUST be obtained within 24 hours, see below.

Table 1: List of drugs where an initial prescription is allowed for APPROVED INDICATIONS ONLY

DRUG

Approved Indication 

Ambisome®

Neutropenic sepsis, endophthalmitis 

Caspofungin

Neutropenic sepsis, ITU 

Cefotaxime

Meningitis, paediatric sepsis 

Ceftazidime

Cystic fibrosis, endophthalmitis, suspected CAPD peritonitis 

Ceftriaxone

Meningitis, supraglottitis, orbital cellulitis, paediatric sepsis, PID

Cefuroxime

Paediatrics (LRTI, AOM) pyrexia in labour, Group B Strep

Clindamycin

Necrotising fasciitis, paediatrics, PID

Gentamicin

Up to 4 days for all indications 

Linezolid

ITU for S aureus pneumonia

Meropenem

ITU, cystic fibrosis, neutropenic sepsis, severe sepsis (penicillin allergy), severe diabetic foot infection (penicillin allergy), necrotising fasciitis 

Piperacillin/tazobactam

Neutropenic sepsis, severe diabetic foot infection

Posaconazole

Haematology prophylaxis 

Teicoplanin

Neutropenic sepsis, surgical prophylaxis

Voriconazole

Neutropenic sepsis step down


Table 2: List of drugs that require authorisation BEFORE prescribing

Amikacin
Anidulafungin
Ceftazidime/avibactam
Ceftolozane/tazobactam
Chloramphenicol (systemic)
Colistimethate sodium
Dalbavancin
Daptomycin
Ertapenem
Fidaxomicin
Fosfomycin (injection)
Meropenem/vaborbactam
Moxifloxacin
Posaconazole (treatment)
Temocillin
Tigecycline
Tobramycin (non-CF)


Authorisation in North Highland

In primary and secondary care, contact the duty consultant microbiologist in Raigmore via the laboratory on Ext 4206 (out of hours, via switchboard) or the infectious diseases physician via switchboard.

Primary care: These antimicrobials should only be used following discussion with, or on the advice of, an infection specialist. This should be recorded in the patient notes.

Secondary care: a code will be provided and must be written:

  • in the notes as part of the Micro/ID discussion,
  • as an 'Antibiotic Indication and Duration' note attached to the antimicrobial drug order on HEPMA.

This code is checked by Pharmacy staff and, if appropriate, the antimicrobial is supplied to the ward.

A supply is made for EACH patient so return unused stock to Pharmacy when the course is complete.

In the absence of a valid authorisation code, no antimicrobial will be supplied, and the ward pharmacist will contact the prescriber who is welcome to discuss with a consultant microbiologist.     

DO NOT try to make up the code yourself – the codes are unique identifiers and fraudulent codes will be detected.


Authorisation in Argyll & Bute

Pharmacy stock for in-patient areas is provided by NHS Greater Glasgow and Clyde. Please note an equivalent authorisation process is not used by NHS GGC.


For glossary of terms see Glossary.  

Abbreviations

  • AOM: Acute otitis media
  • CAPD: Continuous ambulatory peritoneal dialysis
  • CF: Cystic fibrosis
  • ITU: Intensive therapy unit
  • LRTI: Lower respiratory tract infection
  • NS: Neutropenic sepsis
  • PA: Penicillin allergy
  • PID: Pelvic inflammatory disease

Editorial Information

Last reviewed: 29/04/2025

Next review date: 29/04/2028

Author(s): Antimicrobial Management Team.

Version: 3.1

Approved By: TAM subgroup of the ADTC

Reviewer name(s): A Macdonald, Area Antimicrobial Pharmacist.

Document Id: AMT147