Skip to main content
  1. Right Decisions
  2. GGC - Clinical Guidelines
  3. Back
  4. Cancer
  5. Denosumab for hypercalcaemia of malignancy (1198)

Denosumab for hypercalcaemia of malignancy (1198)

Warning

Denosumab is a human monoclonal antibody that can be used for the treatment of hypercalcaemia of malignancy. This guideline advises on prescribing and dosing of denosumab instead of standard treatment with zolendronic acid where the condition is refractory to bisphosphonate therapy or where bisphosphonates are contraindicated due to severe renal impairment, under the guidance of the Specialist Palliative Care Team. This guideline should be considered in conjunction with the Scottish Palliative Care Guideline on Management of hypercalcaemia.

Resources

Use the button below to access this item.

Access this resource

Editorial Information

Last reviewed: 03/04/2025

Next review date: 31/03/2027

Author(s): Paul Gallagher.

Version: 1

Author email(s): paul.gallacher4@nhs.scot.

Approved By: Regional Services Clinical Governance Group

Document Id: 1198

References

https://handbook.ggcmedicines.org.uk/guidelines/electrolyte-disturbances/management-of-hypercalcaemia/ Feb 2023

https://www.medicines.org.uk/emc/product/4675/smpc

Denosumab monograph. Palliative Care Formulary via Medicines Complete https://www.medicinescomplete.com accessed on 17/05/2024

British National Formulary (BNF). https://bnf.nice.org.uk accessed on 17.05.2024

Guideline for the use of denosumab for hypercalcaemia of malignancy: https://rightdecisions.scot.nhs.uk/m/2391/adtc-denosumab-final-june-2023_kerry-mcwilliams.pdf accessed on 17.05.2024